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Do Packed Red Blood Cell Transfusions Really Worsen Oncologic Outcomes in Colon Cancer?
*Ramzi Amri, *Anne Dinaux, *Hiroko Kunitake, Liliana Bordeianou, David Berger
Harvard Medical School/Massachusetts General Hospital, Boston, MA
Objective: Several reports aggregating results from small retrospective studies have argued that perioperative packed red blood cell (PRBC) transfusions may increase the risk of developing metastatic recurrence. This abstract tests this assumption in a large cohort spanning a decade of surgically treated colon cancer patients.
Conclusions: Mortality rates were significantly higher in patients with PRBC transfusions, a finding which is backed by a large body of evidence that associates PRBC transfusion with comorbidity and serious illness, rather that it being specific to a unique disease. However, contrary to earlier evidence, findings in our cohort do not support a hypothesis that perioperative PRBC transfusions have a detrimental effect on recurrence rates of surgically treated colon cancer patients. Further research should explore the reasons behind the discrepancy.
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