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Back to Annual Meeting Program Colon Cancer Metastases are not Infiltrated by Favorably Prognostic T Cells: Evidence for the Escape Phase of the Cancer Immunoediting Hypothesis in Humans *Bryan P Stanifer, *Arief Suriawinata, *Jiang Gui, Richard J Barth, Jr Dartmouth-Hitchcock Medical Center, Lebanon, NH
Objective: The cancer immunoediting theory postulates three states of interaction between the immune system and cancer: elimination, equilibrium and escape. Evidence that the T cell immune response at the site of primary colorectal cancers is a strong predictor of survival supports the concept that primary tumors are in a state of equilibrium. We sought to determine if colorectal cancer metastases were in the escape phase of interaction by evaluating cytotoxic, memory and regulatory T cell immune responses at the site of colorectal cancer metastases and determining whether these responses are associated with patient survival. Back to Annual Meeting Program
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